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CASE REPORT
Year : 2017  |  Volume : 2  |  Issue : 1  |  Page : 16-18

Partial hydatidiform molar gestation following assisted conception


Department of Embryology, The Bridge Clinic, Plot 724 CAD, Umaru Dikko Street, Jabi, Abuja, Nigeria

Correspondence Address:
John Chukwuzitelu Ekweani
The Bridge Clinic, Umaru Dikko Street, Jabi, Abuja
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ajiac.ajiac_6_16

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Molar gestation, with its attendant risk to progress to frank choriocarcinoma, has been reported in the literature. It can follow both spontaneous and assisted conceptions. With the growing popularity of assisted conception techniques for the management of infertility in our setting, it is important to bring to the fore that similar complications could occur and hence should inform the counseling of patients before and during such procedures. We present a 39-year-old nullipara who had in vitro fertilization and frozen embryo transfer. Eight weeks later, she was diagnosed with missed abortion and had manual vacuum aspiration at a private hospital in Zaria. Histopathological examination revealed partial hydatidiform mole, and she was subsequently managed at a tertiary health center in Zaria with six cycles of methotrexate chemotherapy because she was low risk based on the International Federation of Gynecologists and Obstetricians criteria. She was monitored with monthly serum beta-human chorionic gonadotropin (β-HCG) and was placed on combined oral contraceptive pills. The serum β-HCG levels fell to almost undetectable levels and remained so after four cycles of the chemotherapy regimen. Molar pregnancy can follow assisted conception in our environment. This underscores the importance of pretransfer cytogenetic and histopathological assessment of any specimens aspirated following every incomplete/missed abortion. This case also brings to the fore the importance of referral of similar cases to higher levels of care for expert/multidisciplinary management.


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